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3 edition of Design, synthesis, and characterization of amphiphilic [beta]-strand peptides found in the catalog.

Design, synthesis, and characterization of amphiphilic [beta]-strand peptides

David G. Osterman

Design, synthesis, and characterization of amphiphilic [beta]-strand peptides

by David G. Osterman

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  • 32 Currently reading

Published .
Written in English


Edition Notes

Statementby David G. Osterman.
Classifications
LC ClassificationsMicrofilm 86/112 (Q)
The Physical Object
FormatMicroform
Paginationviii, 199 p.
Number of Pages199
ID Numbers
Open LibraryOL2357294M
LC Control Number86890950

Peptide self-assembled nanostructures are very popular in many biomedical applications. Drug delivery is one of the most promising applications among them. The tremendous advantages for peptide self-assembled nanostructures include good biocompatibility, low cost, tunable bioactivity, high drug loading capacities, chemical diversity, specific targeting, and stimuli responsive drug delivery at Cited by: Schweizer, F. Cationic amphiphilic peptides with cancer-selective toxicity. Eur. J. Pharmcol. , Schweizer, F. Design and synthesis of glucose-templated proline-lysine chimera: polyfunctional amino acid chimera with high prolyl cis amide rotamer population. Carbohydr. Book Chapters / Comments. Owens.

Peptide Quantity. Sum of all features from that peptide. Protein Quantity. Sum of all peptides from that protein. Quantitation of a peptide. Across four biological groups. Peptide CV = 8 - 12%. Protein CV = 3 - 4% • Analytical Variability of ~ 35, peptides • Daily QC Sample (pool of QC plasma sample).   So far, available treatment methods rely on the replacement of decayed soft and mineralized tissue with inert biomaterials alone. As an approach to develop novel regenerative strategies and engineer dental tissues, two dental stem cell lines were combined with peptide-amphiphile (PA) hydrogel by:

A low molecular weight peptide-based ambidextrous gelator molecule has been discovered for efficient control of water pollution. The gelator molecules can gel various organic solvents with diverse polarity, e.g. n-hexane, n-octane, petroleum ether, petrol, diesel, aromatic solvents like chlorobenzene, toluene, benzene, o-xylene and even aqueous phosphate buffer of pH Cited by:   Methods. Peptide Synthesis. The linear and cyclic peptides were synthesized by using Boc-based Merrifield solid phase peptide synthesis (18, 19) using anhydrous hydrogen fluoride for cleavage from the methylbenzhydrylamine resin support to provide the targeted peptide 1, which is published as supporting information on the PNAS web site, , summarizes Cited by:


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Design, synthesis, and characterization of amphiphilic [beta]-strand peptides by David G. Osterman Download PDF EPUB FB2

Molecular models of several typical designer amphiphilic peptides. Notes: (A) Surfactant-like peptides composed of hydrophobic amino acids as the tail and one or two hydrophilic amino acids as the head.(B) Bolaamphiphilic peptides composed of two hydrophilic amino acids linked by a section of hydrophobic amino molecular models were generated using the ICM-Pro Cited by: 9.

Design, synthesis, and characterization of amphiphilic helical peptides as models of protein structure Thesis (PDF Available) March with 24 Reads How we measure 'reads'Author: Kurt D.

Berndt. Design, synthesis and characterization of antimicrobial pseudopeptides corresponding to membrane-active peptide. Journal of Peptide Research54 (2), DOI: / by: In amphiphilic desmuramyl peptides 1 and 2, the scalar coupling of the two diastereotopic protons in OCH 2 appear as a pair of doublets at ∼ ppm with 2 J constant being 15 Hz in both compounds (Fig.

2, see also Fig. 5s in Supporting Information for DMP 2). Download: Download high-res image (KB) Download: Download full-size image; Fig. by: 1. Five amphiphilic α-helical peptides of 18 residues containing a hydrophobic Trp residue as a fluorescence probe were designed.

The peptides were made up of hydrophobic Leu and hydrophilic Lys residues of a ratio of, and (abbreviated as Hels 13−5, 11−7, 9−9, 7−11, and 5−13, respectively).

These peptides generate ideal amphiphilic α-helical structures Cited by: Design, synthesis, and characterization of a novel hemoprotein Article in Protein Science 10(2) March with 27 Reads How we measure 'reads'.

All Fmoc amino acid derivatives, reagents, and solvents used in the peptide synthesis were purchased from Applied Biosystem. Thioanisole, 1,2-ethanedithiol, trifluoroethanol (TFE), calcein, and phenol were purchased from Aldrich Chemicals.

All chemicals were reagent grade and used without further purification. Synthesis of peptidesCited by:   1. J Biol Chem. Apr 10;(7) Characterization of an amphiphilic helical structure in beta-endorphin through the design, synthesis, and study of model by: CARMEN SCHOLZ, PhD, is a Professor in the Department of Chemistry at the University of Alabama in Huntsville, where her research concentrates on the synthesis and characterization of biocompatible and biodegradable polymers.

She serves on the editorial boards of 3 journals (including Wiley's Polymer International), has published over 70 papers or proceedings, and edited 5 books.

A Guide to Peptide Design and Applications in Biomedical Research Peptide Handbook GenScript USA Inc. Centennial Ave. peptide design and synthesis to reconstitution and application. The Universe of Peptides Proper synthesis, characterization, and application of peptides. Details of isolating a desired peptide from crude synthetic mixtures and assessment of the peptide's final purity by high-performance liquid chromatography and mass spectrometry are provided.

Beyond the practical importance of synthesis and primary characterization, techniques used to investigate the properties of hydrogels are briefly by: Peptides Frontiers of Peptide Science Proceedings of the Fifteenth American Peptide Symposium June 14–19,Nashville, Tennessee, U.S.A.

Design, synthesis and characterization of heme-peptide conjugates. Angela Lombardi, Flavia Nastri, Luca D. D’Andrea, Ornella Maglio, Gabriella D’Auria, Carlo Pedone et al.

About this book. Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles We demonstrate the design, synthesis and characterization of amphiphilic elastin-like polypeptide (ELP) diblock copolymers that undergo temperature-triggered self-assembly into well-defined spherical micelles.

Bio-inspired synthesis of Cited by:   The authors report the synthesis of an enantiomeric block co-beta-peptide that kills methicillin-resistant Staphylococcus aureus, including biofilm and persister bacterial cells, and disperses Cited by: 2. Cationic amphiphilic polymethacrylate derivatives (PMAs) have shown potential as a novel class of synthetic antimicrobials.

A panel of PMAs with varied ratios of hydrophobic and cationic side chains were synthesized and tested for antimicrobial activity and mechanism of action. The PMAs are shown to be active against a panel of pathogenic bacteria, including a drug-resistant Staphylococcus Cited by:   Miyachi, A.

et al. Multivalent galacto-trehaloses: design, synthesis, and biological evaluation under the concept of carbohydrate modules. Biomacromolecu – (). CASCited by: Antimicrobial peptides are a pivotal component of the invertebrate innate immune system. In this study, we identified a lipopolysaccharide- and β-1,3-glucan-binding protein (LGBP) gene from the pacific abalone Haliotis discus hannai (HDH), which is involved in the pattern recognition mechanism and plays avital role in the defense mechanism of invertebrates immune by: 5.

In this study, the design, synthesis, characterization, and cancer cell death activity of a new class of peptide nucleolipids is described. This thesis will present a new class of palmitamide and nucleolipid derived D-(KLAKLAK) 2 bioconjugates in Chapter 2.

A presentation of its synthesis,Author: Niki K. Rana. Here we report the design, synthesis, and self-assembly of benzothienobenzothiophene (BTBT)–peptide conjugates, the BTBT–peptide (BTBT-C 3 –COHN-Ahx-VVAGKK-Am) and the C 8-BTBT–peptide (C 8-BTBT-C 3 –COHN-Ahx-VVAGKK-Am), as β-sheet forming amphiphilic molecules, which self-assemble into highly uniform nanofibers in water with Cited by: 2.

As more antibiotics are rendered ineffective by drug-resistant bacteria, focus must be shifted towards alternative therapies for treating infections. Although several alternatives already exist in nature, the challenge is to implement them in clinical use.

Advancements within biotechnology, genetic engineering, and synthetic chemistry have opened up new avenues towards the search for therapies Cited by:. Title:SPED-(Styrene-Polyethyleneglycol DiacrylateDecenol) - A Novel Resin for Solid Phase Peptide Synthesis; Synthesis and Characterization of Biologically Potent Endothelin Classes of Peptides VOLUME: 15 ISSUE: 5 Author(s):Mohammedhaneefa A.

Siyad and Gopalakrishnapillai S.V. Kumar Affiliation:Chemical Biology, Rajiv Gandhi Centre for Biotechnology, Poojappura. We developed antimicrobial polypeptides (AMPs) with unprecedented radial amphiphilicity. Unlike typical AMPs characterized by facial amphiphilicity or biomimetic antimicrobial polymers with randomly distributed charged and hydrophobic groups, this class of AMPs is made up of homo-polypeptides that feature a radially amphiphilic (RA) structure and adopt a stable α-helical Cited by:   Keywords: SPOT-synthesis, antimicrobial peptides, peptide synthesis, antimicrobial screening, peptide libraries, substitution analysis, multi-drug resistance, tethered peptides.

Citation: López-Pérez PM, Grimsey E, Bourne L, Mikut R and Hilpert K () Screening and Optimizing Antimicrobial Peptides by Using SPOT-Synthesis.

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